Professor Chung Ji LIU
劉 崇基 教授
Education:
1983-1989 DDS, School of Dentistry, National Yang-Ming University
2000-2002 Master, School of Dentistry, National Yang-Ming University
Experience:
1991-1995 Resident, Veteran General Hospital, Taipei, Taiwan
1995-2008 Attending Physician, MacKay Memorial Hospital, Taipei, Taiwan
2008-2014 Chief, Department of Oral and Maxillofacial Surgery, MacKay Memorial Hospital, Taipei, Taiwan
2014- Chief, Department of Stomatology, Mackay Memorial Hospital, Taiwan
2010- Professor, National Yang Ming University
Published articles (2011-2017)
1. Lee JJ, Kao KC, Chiu YL, Jung CJ, Liu CJ, Cheng SJ, Chang YL, Ko JY, Chia JS. Enrichment of Human CCR6+ Regulatory T Cells with Superior Suppressive Activity in Oral Cancer. J Immunol. 2017 Jul 15;199(2):467-476.
2. Su NW, Wu SH, Chi CW, Liu CJ, Tsai TH, Chen YJ. Metronomic Cordycepin Therapy Prolongs Survival of Oral Cancer-Bearing Mice and Inhibits Epithelial-Mesenchymal Transition. Molecules. 2017 Apr 13;22(4). Select item 27682875
3. Chang CW, Chen YS, Chen CC, Chan IO, Chen CC, Sheu SJ, Lin TW, Chou SH, Liu CJ, Lee TC, Lo JF. Targeting cancer initiating cells by promoting cell differentiation and restoring chemosensitivity via dual inactivation of STAT3 and src activity using an active component of antrodia cinnamomea mycelia. Oncotarget. 2016 Nov 8;7(45):73016-73031. doi: 10.18632/oncotarget.12194.
4. Lin SC, Kao SY, Chang JC, Liu YC, Yu EH, Tseng SH, Liu CJ*, Chang KW.
Up-regulation of miR-187 modulates the advances of oral carcinoma by targeting BARX2 tumor suppressor. Oncotarget. 2016 Sep 20;7(38):61355-61365. doi: 10.18632/oncotarget.11349.
5. Lu WC, Liu CJ, Tu HF, Chung YT, Yang CC, Kao SY, Chang KW, Lin SC.miR-31 targets ARID1A and enhances the oncogenicity and stemness of head and neck squamous cell carcinoma. Oncotarget. 2016 Aug 30;7(35):57254-57267. doi: 10.18632/oncotarget.11138.
6. Liu CJ, Lin JS, Cheng HW, Hsu YH, Cheng CY, Lin SC. Plasma miR-187* is a potential biomarker for oral carcinoma. Clin Oral Investig. 2017 May; 21(4):1131-1138. doi: 10.1007/s00784-016-1887-z. Epub 2016 Jun 20.
7. Chen YF, Yang CC, Kao SY, Liu CJ, Lin SC, Chang KW. MicroRNA-211 Enhances the Oncogenicity of Carcinogen-Induced Oral Carcinoma by Repressing TCF12 and Increasing Antioxidant Activity. Cancer Res. 2016 Aug 15;76(16):4872-86. doi: 10.1158/0008-5472.CAN-15-1664. Epub 2016 May 24.
8. Hung KF, Liu CJ, Chiu PC, Lin JS, Chang KW, Shih WY, Kao SY, Tu HF. MicroRNA-31 upregulation predicts increased risk of progression of oral potentially malignant disorder. Oral Oncol. 2016 Feb;53:42-7. doi: 10.1016/j.oraloncology.2015.11.017.
9. Lai KC, Liu CJ, Lin TJ, Mar AC, Wang HH, Chen CW, Hong ZX, Lee TC Blocking TNF-α inhibits angiogenesis and growth of IFIT2-depleted metastatic oral squamous cell carcinoma cells. Cancer Lett. 2016 Jan 28;370(2):207-15. doi:
10. Hsia KT, Liu CJ, Mar K, Lin LH, Lin CS, Cheng MF, Lee HS, Chiu SY.Impact of apurinic/apyrimidinic endonuclease 1/redox factor-1 on treatment response and survival in oral squamous cell carcinoma.
11. Liu CJ, Chang WJ, Chen CY, Sun FJ, Cheng HW, Chen TY, Lin SC, Li WC.Dynamic cellular and molecular modulations of diabetes mediated head and neck carcinogenesis.Oncotarget. 2015 Aug 21.
12. Tu HF, Chang KW, Cheng HW, Liu CJ*.Upregulation of miR-372 and -373 associates with lymph node metastasis and poor prognosis of oral carcinomas.Laryngoscope. 2015 Jul 7. doi: 10.1002/lary.25464.
13. Yeh LY, Liu CJ, Wong YK, Chang C, Lin SC, Chang KW. miR-372 inhibits p62 in head and neck squamous cell carcinoma in vitro and in vivo. Oncotarget. 2015 Mar 20;6(8):6062-75.
14. Lin HP, Liu CJ, Chiang CP.Spindle cell lipoma of the tongue.J Formos Med Assoc. 2015 May;114(5):477-9. doi: 10.1016/j.jfma.2014.12.009. Epub 2015 Feb 12.
15. Su NW, Liu CJ, Leu YS, Lee JC, Chen YJ, Chang YF.Prolonged radiation time and low nadir hemoglobin during postoperative concurrent chemoradiotherapy are both poor prognostic factors with synergistic effect on locally advanced head and neck cancer patients.Onco Targets Ther. 2015 Jan 28;8:251-8.
16. Su NW, Leu YS, Lee JC, Liu CJ, Cheng CY, Lin JS, Chen YJ, Chen CK, Fang IC, Hsieh RK, Chang YF.EGF and EGFR genetic polymorphisms predict prognosis in locally advanced pharyngolaryngeal squamous cell carcinoma patients receiving postoperative concurrent chemoradiotherapy.Onco Targets Ther. 2014 Nov 28;7:2197-204. doi:
17. Hsia KT, Liu CJ, Mar K, Lin LH, Lin CS, Cheng MF1, Lee HS, Chiu SY.The impact of apurinic/apyrimidinic endonuclease 1/redox factor-1 on treatment response and survival in oral squamous cell carcinoma.Head Neck. 2014 Dec 6. doi: 10.1002/hed.23927.
18. Chen HF, Huang CH, Liu CJ, Hung JJ, Hsu CC, Teng SC, Wu KJ. Nat Commun. 2014 Aug 22;5:4697. doi: 10.1038/ncomms5697.
19. Tseng SH, Yang CC, Yu EH, Chang C, Lee YS, Liu CJ, Chang KW, Lin SC.K14-EGFP-miR-31 transgenic mice have high susceptibility to chemical-induced squamous cell tumorigenesis that is associating with Ku80 repression. Int J Cancer. 2015 Mar 15;136(6):1263-75. doi: 10.1002/ijc.29106. Epub 2014 Aug 6.
20. Yang DF, Chen JH, Chiang CP, Huang Z, Lee JW, Liu CJ, Chang JL, Hsu YC Improve efficacy of topical ALA-PDT by calcipotriol through up-regulation of coproporphyrinogen oxidase.Photodiagnosis Photodyn Ther. 2014 Sep;11 (3):331-41. doi: 10.1016/j.pdpdt.2014.05.001. Epub 2014 Jun 4.
21. Hung PS, Tu HF, Kao SY, Yang CC, Liu CJ, Huang TY, Chang KW, Lin SC.miR-31 is upregulated in oral premalignant epithelium and contributes to the immortalization of normal oral keratinocytes.Carcinogenesis. 2014 May; 35(5):1162-71. doi: 0.1093/carcin/bgu024. Epub 2014 Jan 30.
22. Liu CJ*, Shen WG, Peng SY, Cheng HW, Kao SY, Lin SC, Chang KW.miR-134 induces oncogenicity and metastasis in head and neck carcinoma through targeting WWOX gene.Int J Cancer. 2014 Feb 15;134(4):811-21. doi: 10.1002/ijc.28358.
23. Chia-Chun Lu, Tréjaut John, Chieh-Yuan Cheng, Chu-Sheng Lin, Chung-Ji Liu*.HLA typing in Taiwanese patients with oral squamous cell carcinoma Journal of Dental Sciences, Volume 9, Issue 1, March 2014, Pages 41–48
24. Jiun-Sheng Lin, Chieh-Yuan Cheng, Chung-Ji Liu*.Oral uracil and tegafur as postoperative adjuvant metronomic chemotherapy in patients with advanced oral squamous cell carcinoma.Journal of Dental Sciences Available online 4 July 2015
25. Hung PS, Liu CJ, Chou CS, Kao SY, Yang CC, Chang KW, Chiu TH, Lin SC.miR-146a enhances the oncogenicity of oral carcinoma by concomitant targeting of the IRAK1, TRAF6 and NUMB genes.PLoS One. 2013 Nov 26;8(11):e79926. doi: 10.1371/journal.pone.0079926. eCollection 2013.
26. Chang KW, Kao SY, Wu YH, Tsai MM, Tu HF, Liu CJ, Lui MT, Lin SC.Passenger strand miRNA miR-31* regulates the phenotypes of oral cancer cells by targeting RhoA.Oral Oncol. 2013 Jan;49(1):27-33.
27. Lee TC, Huang CY, Lo JF.Active Component of Antrodia cinnamomea Mycelia Targeting Head and Neck Cancer Initiating Cells through Exaggerated Autophagic Cell Death.Evid Based Complement Alternat Med. 2013; 2013:946451. doi: 0.1155/2013/946451. Epub 2013 Jun 12.18.
28. Chu TH, Yang CC, Liu CJ, Lui MT, Lin SC, Chang KW. miR-211 promotes the progression of head and neck carcinomas by targeting TGFβRII. Cancer Lett. 2013 Aug 28;337(1):115-24. doi: 10.1016/j.canlet.2013.05.032.
29. Tu HF, Liu CJ, Chang CL, Wang PW, Kao SY, Yang CC, Yu EH, Lin SC, Chang KW.The association between genetic polymorphism and the processing efficiency of miR-149 affects the prognosis of patients with head and neck squamous cell carcinoma.PLoS One. 2012;7(12):e51606. doi: 10.1371/journal.pone.0051606.
30. Liu CJ*, Tsai MM, Tu HF, Lui MT, Cheng HW, Lin SC. miR-196a Overexpression and miR-196a2 Gene Polymorphism Are Prognostic Predictors of Oral Carcinomas.Ann Surg Oncol. 2012 Nov 9.
31. Liu SH, Chao KS, Leu YS, Lee JC, Liu CJ, Huang YC, Chang YF, Chen HW, Tsai JT, Chen YJ. Guideline and preliminary clinical practice results for dose specification and target delineation for postoperative radiotherapy for oral cavity cancer.Head Neck. 2014 Mar 14. doi: 10.1002/hed.23692.
32. Lai KC, Liu CJ, Chang KW, Lee TC.Depleting IFIT2 mediates atypical PKC signaling to enhance the migration and metastatic activity of oral squamous cell carcinoma cells.Oncogene. 2013 Aug 8;32(32):3686-97. doi: 10.1038/onc.2012.384
33. Chang KW, Kao SY, Wu YH, Tsai MM, Tu HF, Liu CJ, Lui MT, Lin SC. 2013 Jan, Passenger strand miRNA miR-31* regulates the phenotypes of oral cancer cells by targeting RhoA. Oral Oncol, 49(1):27-33. doi: 10.1016/j.oraloncology.2012.07.003.
34. Tu HF, Chang KW, Chiang WF, Liu CJ, Yu EH, Liu ST, Lin SC. 2011 Mar, The frequent co-expression of the oncogenes PIK3CA and PAK1 in oral carcinomas. Oral Oncol, 47(3):211-6.
35. Yang CC, Hung PS, Wang PW, Liu CJ, Chu TH, Cheng HW, Lin SC. 2011 May, miR-181 as a putative biomarker for lymph-node metastasis of oral squamous cell carcinoma. J Oral Pathol Med, 40(5):397-404.
36. Liu CJ, Lin SC, Yang CC, Cheng HW, Chang KW. 2012 Feb, Exploiting salivary miR-31 as a clinical biomarker of oral squamous cell carcinoma. Head Neck, 34(2):219-24
37. rs2910164 polymorphism in pre-mir-146a and oral carcinoma progression. Oral Oncol, 48(5):404-8.
38. Su NW, Leu YS, Lee JC, Chen YJ, Chen HW, Liu CJ, Chang YF. 2011 Dec, Comparison of the efficacy and toxicity of two dose levels of cisplatin/5-fluorouracil as the chemoradiotherapy regimen for the treatment of locally advanced squamous cell carcinoma of the head and neck. Acta Otolaryngol, 131(12):1333-40.
39. Tseng YH, Chang KW, Yang CC, Liu CJ, Kao SY, Liu TY, Lin SC. 2012 Feb, Association between areca-stimulated vimentin expression and the progression of head and neck cancers. Head Neck, 34(2):245-53. doi: 10.1002/hed.21726. Epub 2011 Mar 7.
40. Tzong-Ming Shieh, Shun-Yao Ko, Shu-Shin Chang, Kuo-Wei Chang, Yin-Hua Shih, Chung-Ji Liu*. 2011 Dec, Lysyl oxidase-like 3 mRNA expression indicates poor survival from oral squamous cell carcinoma. Journal of Dental Sciences, 6(4):205-209.
41. Yong-Kie Wong, Li-Tsu Lee, Chung-Ji Liu*. 2011 Sep, Hypermethylation of MGMT and DAPK gene promoters is associated with tumorigenesis and metastasis in oral squamous cell carcinoma. Journal of Dental Sciences, 6(3):158-164.
42. Yang CJ, Shen WG, Liu CJ, Chen YW, Lu HH, Tsai MM, Lin SC. 2011 Aug, miR-221 and miR-222 expression increased the growth and tumorigenesis of oral carcinoma cells. J Oral Pathol Med, 40(7):560-6
43. Lo JF, Yu CC, Chiou SH, Huang CY, Jan CI, Lin SC, Liu CJ, Hu WY, Yu YH. 2011 Mar, The epithelial-mesenchymal transition mediator S100A4 maintains cancer-initiating cells in head and neck cancers. Cancer Res, 71(5):1912-23.
44. Tseng YH, Yang CC, Lin SC, Cheng CC, Lin SH, Liu CJ, Chang KW. 2011 Feb, Areca nut extract upregulates vimentin by activating PI3K/AKT signaling in oral carcinoma. J Oral Pathol Med, 40(2):160-6
45. Tu HF, Liu CJ, Liu SY, Chen YP, Yu EH, Lin SC, Chang KW. 2011 Mar, Serum decoy receptor 3 level: a predictive marker for nodal metastasis and survival among oral cavity cancer patients. Head Neck, 33(3):396-402.
