UP to date of MRONJ (medication related osteonecrosis of jaw)
Professor Jae-min SONG
Pusan National University
KOREA
Since Marx reported
BRONJ cases in 2003, BRONJ has been reported for more than 10 years, and many
studies on the etiology, diagnosis and treatment of BRONJ have been performed
in the oral and maxillofacial surgery field. Studies have shown that
bisphosphonates have been associated with increased use of Bisphophontate as a
treatment for osteoporosis since 1990. In recent years, denosumab has been used
as a RANKL inhibitor in addition to bisphosphonates. The jaw necrosis caused by
these drugs called MRONJ.
Today I will present
about these drugs that cause jaw necrosis, the mechanism, diagnosis and
treatment standards of each country. In treatment of MRONJ, Surgical treatment
can provide a high level of recovery. We will review the surgical
considerations. In addition to surgical treatment, many adjunctive modalities
such as LLLT (low level laser therapy), HBO (hyperbaric oxygen therapy),
platelet concentrate and fluorescent marking were using.
We will also
investigate the recent trends in the use of recombinant hormone, growth factors
and stem cells.
